We keep learning regularly of how new frontiers of science have been reached, and of the recognition awarded to this or that scientist, or groups of scientists. And we keep wondering, what are such people made of, at what level of intelligence do they dwell, are they something above us mere mortals. (And this seems a feeling shared by Venki's wife Vera, who he says remarked after learning of his Nobel: "I thought you had to be really smart to win one of those!") Here, then, is a first person account by a Nobel laureate who has dedicated his life to researching into the ribosome, the 'Gene Machine' of the title which helps construct our body and mind by helping synthesize the various proteins which make it up.
The book reads like a thriller! On how different groups of scientists across continents were striving to be the first to crack specific aspects of the workings of the ribosome (and, left unsaid, to have a fighting chance for the Chemistry Nobel, which Venki shared with two others in 2009). And the story unfolds as that of an underdog 'coming from behind' to breast the tape since, for a large part of his scientific career, Venki senses that he's somewhat of an outsider among the cozy group of scientists working on different facets of ribosome research. In fact, this seems to have influenced his worldview of the whole system of awards and rewards including the Nobel, as he writes at some length in the chapter aptly titled 'The Politics of Recognition'.
What strikes the reader quite early is the humility with which Venki writes about his life's passion. Almost the first 40% of the book is focused on how other stalwart scientists, who worked in the domain since decades, helped bring the field of ribosome research into a certain state of maturity, even before Venki's life work begins. And not only in ribosome research itself, there were so many who helped perfect the equipments and sensors which would later help scientists and researchers make sense of the minute articles they were looking at, articles within cells which couldn't even be sensed, much less seen, with any kind of X-ray (till electron microscopes made it a bit easier).
All through the book, Venki's passion for the domain itself comes through shining, bereft of any attempt at self-aggrandizement. He's very conscious of the stellar work his 'competitors' were doing in the 'race' to crack the secrets of the ribosome, a race which seems still on, though perhaps now shifted to a better track and with better equipment, as Venki writes in the Epilogue. And he's effusive in his praise for the junior scientists who chose to be associated with his labs over the years, describing their personalities (and eccentricities!) in some detail, besides of course the aspects of their work which helped along the main effort. Throughout, he refers to "our" work, rather than 'my'. It's touching to see the picture of Venki celebrating in Stockholm, while there to accept the Nobel, with almost all the associates who had worked with him at different stages of his career spanning across four decades.
Venki touches extensively on the issue of collaboration, in science as in other domains. Of how collaboration "works best when people know each other well and like working together, or when they bring complementary expertise to bear on a problem that no one group can tackle alone". And while being aware of the fierce competition in the field, he also admits that "even when scientists are competing, they are actually using one another's advances to make progress and are thus collaborating, albeit involuntarily". In fact, he seems to treat due acknowledgement of such contributions by others as professional courtesy, bristling at one point when referring to an incident when another scientist used his work but didn't acknowledge that during a lecture.
One may wonder at the felicity with which an accomplished scientist like Venki writes in plain language (mostly!) the story of his trials and tribulations, to make eminent sense to the lay reader. But then hints of that are strewn across the book, as Venki (and his team) had to write about their scientific discoveries not only for scientific publications like 'Science' or 'Nature', but also to make presentations to college students and even general public while on 'The Ribosome Road Show'.
This, though, is no hagiography. Venki doesn't flinch from describing his own foibles, mostly in the scientific arena. His missteps, his misjudgments (both of people and scientific approaches), and his frequent irritability. He also describes briefly the uproar that resulted from his almost dismissing any connection with his birth country India, after being awarded the Nobel, especially with his "accident of birth" comment. He gives his reasons, but his expression of surprise (not pleasant surprise!) both at getting messages from Indian President and Prime Minister, besides US Prez and UK PM, and also at being awarded one of India's highest honors, are bound to leave a sour taste for Indian readers. Though this gels overall with his views, expressed earlier in the book, on other honors based on the Nobel award, he seemingly did try to make amends of some sort by accepting fellowship from Baroda university in India where he studied in the early part of his life till nineteen, along with Cambridge and Utah institutions where he worked, while rejecting all others.
The beauty of this book is that, even shorn of the scientific content (and there is quite a lot of arcane stuff there, naturally), it provides fascinating insights into the world of science and scientists, from the horse's mouth so to say. And if one is a wee bit interested in the scientific aspects, the book has sufficient material for the reader to make sense of any discussion on ribosome and, with some effort, even to talk intelligently on the rudiments of ribosome, including a bit about the functions of large and small subunits, RNA, DNA and proteins.
The book reads like a thriller! On how different groups of scientists across continents were striving to be the first to crack specific aspects of the workings of the ribosome (and, left unsaid, to have a fighting chance for the Chemistry Nobel, which Venki shared with two others in 2009). And the story unfolds as that of an underdog 'coming from behind' to breast the tape since, for a large part of his scientific career, Venki senses that he's somewhat of an outsider among the cozy group of scientists working on different facets of ribosome research. In fact, this seems to have influenced his worldview of the whole system of awards and rewards including the Nobel, as he writes at some length in the chapter aptly titled 'The Politics of Recognition'.
What strikes the reader quite early is the humility with which Venki writes about his life's passion. Almost the first 40% of the book is focused on how other stalwart scientists, who worked in the domain since decades, helped bring the field of ribosome research into a certain state of maturity, even before Venki's life work begins. And not only in ribosome research itself, there were so many who helped perfect the equipments and sensors which would later help scientists and researchers make sense of the minute articles they were looking at, articles within cells which couldn't even be sensed, much less seen, with any kind of X-ray (till electron microscopes made it a bit easier).
All through the book, Venki's passion for the domain itself comes through shining, bereft of any attempt at self-aggrandizement. He's very conscious of the stellar work his 'competitors' were doing in the 'race' to crack the secrets of the ribosome, a race which seems still on, though perhaps now shifted to a better track and with better equipment, as Venki writes in the Epilogue. And he's effusive in his praise for the junior scientists who chose to be associated with his labs over the years, describing their personalities (and eccentricities!) in some detail, besides of course the aspects of their work which helped along the main effort. Throughout, he refers to "our" work, rather than 'my'. It's touching to see the picture of Venki celebrating in Stockholm, while there to accept the Nobel, with almost all the associates who had worked with him at different stages of his career spanning across four decades.
Venki touches extensively on the issue of collaboration, in science as in other domains. Of how collaboration "works best when people know each other well and like working together, or when they bring complementary expertise to bear on a problem that no one group can tackle alone". And while being aware of the fierce competition in the field, he also admits that "even when scientists are competing, they are actually using one another's advances to make progress and are thus collaborating, albeit involuntarily". In fact, he seems to treat due acknowledgement of such contributions by others as professional courtesy, bristling at one point when referring to an incident when another scientist used his work but didn't acknowledge that during a lecture.
One may wonder at the felicity with which an accomplished scientist like Venki writes in plain language (mostly!) the story of his trials and tribulations, to make eminent sense to the lay reader. But then hints of that are strewn across the book, as Venki (and his team) had to write about their scientific discoveries not only for scientific publications like 'Science' or 'Nature', but also to make presentations to college students and even general public while on 'The Ribosome Road Show'.
This, though, is no hagiography. Venki doesn't flinch from describing his own foibles, mostly in the scientific arena. His missteps, his misjudgments (both of people and scientific approaches), and his frequent irritability. He also describes briefly the uproar that resulted from his almost dismissing any connection with his birth country India, after being awarded the Nobel, especially with his "accident of birth" comment. He gives his reasons, but his expression of surprise (not pleasant surprise!) both at getting messages from Indian President and Prime Minister, besides US Prez and UK PM, and also at being awarded one of India's highest honors, are bound to leave a sour taste for Indian readers. Though this gels overall with his views, expressed earlier in the book, on other honors based on the Nobel award, he seemingly did try to make amends of some sort by accepting fellowship from Baroda university in India where he studied in the early part of his life till nineteen, along with Cambridge and Utah institutions where he worked, while rejecting all others.
The beauty of this book is that, even shorn of the scientific content (and there is quite a lot of arcane stuff there, naturally), it provides fascinating insights into the world of science and scientists, from the horse's mouth so to say. And if one is a wee bit interested in the scientific aspects, the book has sufficient material for the reader to make sense of any discussion on ribosome and, with some effort, even to talk intelligently on the rudiments of ribosome, including a bit about the functions of large and small subunits, RNA, DNA and proteins.
